The Huff lab and friends got together to celebrate the recent marriage of Hao Hu and Jing Xie. The party included Sichuan fare from Mala Bistro, a two-tiered wedding cake, and lots of friends! Thank you to everyone that came out to share their joy with the happy couple!
Felipe R Lorenzo, Chad Huff, Mikko Myllymäki, Benjamin Olenchock, Sabina Swierczek1, Tsewang Tashi, Victor Gordeuk, Tana Wuren, Ge Ri-Li, Donald A McClain, Tahsin M Khan, Parvaiz A Koul, Prasenjit Guchhait, Mohamed E Salama, Jinchuan Xing, Gregg L Semenza, Ella Liberzon, Andrew Wilson, Tatum S Simonson, Lynn B Jorde, William G Kaelin Jr, Peppi Koivunen, Josef T Prchal (2014): A genetic mechanism for Tibetan high-altitude adaptation. In: Nature Genetics, 2014.
This paper provides strong functional evidence that two nonsynonymous variants are responsible for high-altitude adaptation at the EGLN1 locus in Tibet. To our knowledge, this is the only example of a polymorphic coadapted gene complex in a human population. (If anyone knows of other examples, please let us know!)