The Huff lab is happy to announce the advanced online publication of "A genetic mechanism for Tibetan high-altitude adaptation" in the journal Nature Genetics.
A genetic mechanism for Tibetan high-altitude adaptation. In: Nature Genetics, 2014.
This paper provides strong functional evidence that two nonsynonymous variants are responsible for high-altitude adaptation at the EGLN1 locus in Tibet. To our knowledge, this is the only example of a polymorphic coadapted gene complex in a human population. (If anyone knows of other examples, please let us know!)